Negen - Diabetes

Diabetes is one of Finland's biggest national diseases. There are approximately 500,000 diabetics in Finland. In addition to these, it is estimated that there are some 150,000 people suffering from Type 2 diabetes without their knowledge. Both Type 1 and Type 2 diabetes are multifactorial diseases, which are caused by genetic, lifestyle and environmental factors. In the analysis, we examine your risk of contracting diabetes by conducting a gene test and lifestyle questionnaire.

The Negen - Diabetes gene test package contains a total of 237 genetic variants related to diabetes and its common risk factors. When these are combined with the responses to the lifestyle questionnaire, they provide an estimate of your risk of contracting diabetes. The manner in which environmental factors affect the individual risk of contracting Type 1 diabetes is still not fully understood.

Genetic panels included in the test

Tyypin 2 diabetesta (aikuistyypin diabetes) sairastaa Suomessa n. 500 000 ihmistä ja se on merkittävimpiä kansantautejamme. Diabetes voi johtaa useisiin lisäsairauksiin, kuten verkkokalvon, munuaisten ja ääreishermoston vaurioitumiseen.

Tyypin 2 diabetes syntyy perimän, elintapojen ja ympäristön yhteisvaikutuksesta. Samat geenit, jotka suojasivat esi-isiämme menehtymästä ravinnon puutteeseen edistävät nykyihmisessä sairastumista aikuistyypin diabetekseen. Alttius sairastua periytyy voimakkaasti: riski on kaksinkertainen, jos toisella vanhemmista on tyypin 2 diabetes ja viisinkertainen, jos tauti on molemmilla vanhemmilla. Elintapariskeistä merkittävin on ylipaino.

Aikuistyypin diabeteksen hoitoon on useita lääkkeitä. Diabetesta sairastavien hoidossa erityistä huomiota kiinnitetään lisäksi kolesteroli- ja verenpainearvoihin.

Lukuisia sairaudelle altistavia geenialueita tunnetaan. Negen-geenianalyysi selvittää kattavasti tunnettuja geenimuutoksia.

Genetic variants included 1000

Ylipaino on seurausta liiallisesta energiansaannista suhteessa energian kulutukseen pitkällä aikavälillä. Yksilöllinen alttius lihomiseen on osittain geneettisesti säänneltyä. Testimme avulla voit selvittää geneettistä taipumustasi ylipainoon.

Genetic variants included 97

Veren kolesteroliaineenvaihdunnan häiriöt eli dyslipidemiat lisäävät riskiä sairastua sydän- ja verisuonisairauksiin sekä Alzheimerin tautiin. Testimme avulla voit selvittää onko sinulla perinnöllistä taipumusta rasva-aineenvaihdunnan häiriöihin.

Genetic variants included 204

Kohonnut verenpaine on sydän- ja verisuonitautien tärkeä riskitekijä. Erityisen tärkeää verenpaineen hoito on diabeetikoilla. Korkea verenpaine lisää myös Alzheimerin taudin riskiä.

Verenpainelukemiin vaikuttavat sekä yläpaine eli systolinen verenpaine että alapaine eli diastolinen verenpaine. Sekä ylä- että alapaineen tausta on osittain geneettinen ja molempiin tunnetaan lukuisia vaikuttavia geenimarkkereita. Testimme avulla voit selvittää onko sinulla perinnöllistä taipumusta korkeaan verenpaineeseen.

Genetic variants included 119

Miten Negen geenianalyysi tehdään?

1. Lifestyle questionnaire

Using an online lifestyle questionnaire, we determine the impact that environmental factors and external lifestyle factors will have on your body. The lifestyle questionnaire is a key part of the test, ensuring that your report is as accurate and reliable as possible. You can fill out the lifestyle questionnaire after logging into the Negen website.

2. Gene analysis

Your DNA will be extracted from a saliva sample. After You order a genomic analysis, we will send You a test kit that contains all necessary equipment for a high quality sample. We conduct a technical analysis of your genome to determine how hereditary factors affect your risk of contracting a disease based on scientifically verifiable risk factors. Gene analysis is based on markers, i.e. a known point on a chromosome in a person's DNA sequence. In Negen's tests genetic markers are selected by a Finnish genetic research team based on scientifically proven studies and articles.

3. Easy-to-understand reports

An easy-to-understand report is created from the combined results of the gene analysis information and lifestyle questionnaire responses. The accuracy of our report is further enhanced by an extensive volume of genetic material, with which your personal results can be compared. The report includes practical advice on how to minimise possible risk factors. The genetic and lifestyle risk assessment is based on Finnish population data maintained by National Institute for Welfare and Health (THL).

4. Physician network support

We have partnership agreements with physicians practising in different fields of medicine to conduct follow-up examinations or address findings requiring treatment. If the test results indicate a need for a follow-up examination or monitoring, we can recommend a medical specialist from our physician network.

5. Future possibilities

New genetic findings affecting health are constantly being made. We develop our service based on these new findings, utilising the latest research results to promote your health.

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The test gives you a comprehensive assessment of the risks for the most common non communicable diseases and provides you tools to preserve Your health and maximize your healthy years.

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